Need help in Physiology!

[Miss Saihati]

Hi,,

i'm a medical student " junior cycle 1 & 2 " i need some answers for my qustions that i'm going to post in this thread ,, i dont have time to search for the answers my self due to some issues that i'm facing but i need these answers in order to understand the material that i'm going to take a test in it in two months so i'l be gratefull for whoever got the time to help me & answer the questions..

we can also use this thread to post questions about basic sicence {physiology, Anatomy, biochemistery,,,} to help junior students ..

(plz mention some referrance "if u can " & dont answer if you are not sure! Thanks !)

1- could plasma [glucose] exceed the threshold of approx. 14mmol/l & not result in glycosuria ? with simple explaination ...

--> i'm thinking if the GFR decreased so the afterload of glucose will not exceed the Tmax of the transporter ? is there any other possibilities ?

2- approx. 158.5 L of salt & water are reabsorbed per day. how does this get back onto the blood ?

--> i know its somethig with pressure but i cant remember ?

i'l be posting more quetions soon ...

best regards,
(F)

[Miss Saihati]

3- familial glycosuria result in glucose in urine despite the normal plasma [glucose] ,, due to improper functioning of the renal tubules ..but what kind of improper functioning? i want to know it in more details ..a referrance or a website will be helpful if no one got the time to answer ..

[san]

I am not sure if you've already got the answers to your questions, but here are my thoughts:

1) I think this situation is most likely to arise as a result of an intrinsic malfunction of the filtration apparatus of the kidneys, leading to a low GFR.

2) The movement of water and solutes from the interstitial space to the plasma are mainly dictated by the Starling forces which are determined by the hydrostatic pressures and oncotic pressures in the peritubular capillary and the interstitial space. Normally, the sum of the Starling forces favours the movement of solute and water from the interstitial fluid to the plasma.

3) Renal glycosuria is a benign autosomal recessive defect of tubular reabsorption of glucose, caused by mutations of the sodium/glucose cotransporter SGLT2. Glucose appears in the urine in the presence of a normal blood glucose concentration, as you have mentioned.

[Miss Saihati]

Thanks San ,,, you helped alot ,,

[anugrah84]

3- familial glycosuria result in glucose in urine despite the normal plasma [glucose] ,, due to improper functioning of the renal tubules ..but what kind of improper functioning? i want to know it in more details ..a referrance or a website will be helpful if no one got the time to answer ..

answer of question 3)due to some infections such as bacterial inf and other etiology is aslo there,there will be inflammatory rections at glomerular capillary network and due to the chemical mediators such as interleukins etc the pore size for filtering the glomerular filtrate will increase and even glucose can come in primary urine even though its not high in plasma level.for more details contact me anugrah dubey,3rd year medical student of hainan medical college : anugrah84@gmail.com

[anugrah84]

answer of question 3)due to some infections such as bacterial inf and other etiology is aslo there,there will be inflammatory rections at glomerular capillary network and due to the chemical mediators such as interleukins etc the pore size for filtering the glomerular filtrate will increase and even glucose can come in primary urine even though its not high in plasma level

[Miss Saihati]

thanks anugrah ,,

[anugrah84]

your welcome