pharmacological therapy of osteoarthritis :

1.NSAID,and if using non-selective COX1/2 inhibitors then adding omeprazol to limit their gastrotoxicity
2.Antidepressants
3.Chondroprotective agents(glucosamine,chondroitin sulfat...)
Is this valid contemporary therapy of Osteoarthritis?

Also,is it confirmed that selective COX2 inhibitors(NSAID) arent more effective then standrad,traditional non-selective COX1/2?
Do you suggest using selective inhibitors always when treating Osteoarthritis?