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  1. #1
    GRD
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    Transmural Stomach hemorrage?

    What is the definition of a "transmural stomach hemorrhage?"
    Am I correct in thinking that it is a hemorrhage of the wall of the stomach organ that causes blood circulating the body to abnormally spill into the stomach?
    Also, if blood is able to flow INTO the stomach when this type of hemorrhage occurs, could substances contained within the stomach not in fact also leak/exit OUT of the stomach (entering the bloodstream) via the same entrance? It, to me, seems to make logical sense that substances would be able to leak both ways (in and out) rather than just one. Surely, if there is some kind of hole in the wall of the stomach organ, substances within the stomach (such as ingested medication) could just as easily leak out through this hole and enter the bloodstream as blood pumping around the body can pass through this hole and enter the stomach? Would this not especially be the case if a person suffering with a transmural stomach hemorrhage is moved around a lot, causing the stomach contents to be physically disturbed?
    My apologies if this question is poorly phrased! I am very new to biology and medicine and often have difficulty explaining my thoughts. I am urgently seeking some information on this topic, so any help would be hugely appreciated!


    If you feel this question would be better another area of the forum, please let me know .

    Many thanks!



  2. #2
    Senior Member melon's Avatar
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    Quote Originally Posted by GRD View Post
    What is the definition of a "transmural stomach hemorrhage?"
    Am I correct in thinking that it is a hemorrhage of the wall of the stomach organ that causes blood circulating the body to abnormally spill into the stomach?
    Also, if blood is able to flow INTO the stomach when this type of hemorrhage occurs, could substances contained within the stomach not in fact also leak/exit OUT of the stomach (entering the bloodstream) via the same entrance? It, to me, seems to make logical sense that substances would be able to leak both ways (in and out) rather than just one. Surely, if there is some kind of hole in the wall of the stomach organ, substances within the stomach (such as ingested medication) could just as easily leak out through this hole and enter the bloodstream as blood pumping around the body can pass through this hole and enter the stomach? Would this not especially be the case if a person suffering with a transmural stomach hemorrhage is moved around a lot, causing the stomach contents to be physically disturbed?
    My apologies if this question is poorly phrased! I am very new to biology and medicine and often have difficulty explaining my thoughts. I am urgently seeking some information on this topic, so any help would be hugely appreciated!


    If you feel this question would be better another area of the forum, please let me know .

    Many thanks!
    "Transmural" simply means 'across the wall' for example transmural inflammation in Crohn's disease means inflammation that affects the entire thickness of the bowel wall. Transmural haemorrhage is not a term I am familiar with - do you mean transmural haemorrhagic necrosis?

    Either way, the blood system is a high pressure system and when it bleeds into the GI tract, it is entering a low pressure system. So there is only really one way flow - that being blood into, for example, the stomach. Stomach contents entering the blood stream would be a bit like a leaf floating passively upstream of a river - it just doesn't happen because of the pressure difference between the two lumens.

    Hope this helps, why do you want to know anyway?
    Dr. Batman SHO

  3. #3
    GRD
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    Thank you very much for taking the time to get back to me with this excellent information. This is tremendously helpful and appreciated!

    I'm very new to this kind Biology so it can be difficult to determine whether I'm investigating ideas correctly. I often ask questions on forums but, after receiving no reply, wonder if I am understanding these ideas properly, thus wording my posts in a way others can understand!
    In this case, I am doing an exercise which requires me to investigate the reasons for particular substances being found in a human individual's bloodstream and stomach after they have suffered a "transmural hemorrhage" of the "stomach." This was phrased as: "stomach - transmural hemorrhage" on the exercise description (I thought it might be referred to as "transmural stomach hemorrhage" - but am not yet familiar with different terminology. You mention "transmural haemorrhagic necrosis." Do you think I have perhaps misinterpreted what my exercise described as "stomach - transmural hemorrhage"?)
    I assumed it would mean a hemorrhage where substances pass through the stomach wall, and concluded that it would explain why substances usually found in the blood were stated to also be found in the stomach on the exercise (due to bleeding into the stomach cavity). However, in this exercise, subtances you would expect to find in the stomach are also stated to be found in the bloodstream at the same time.

    The essential point in this exercise is to corroborate or refute the statements made about the whereabouts of these substances in the body after this hemorrhage of the stomach has occurred. I was able to back up the statement made about substances normally found in the blood being in the stomach as a result of the hemorrhage causing bleeding INTO the stomach, but was unsure what to make of the statement claiming that substances from the stomach were also found in the bloodstream. It brought me to question whether this transmural hemorrhage can also cause the contents of the stomach to leak out and enter the bloodstream (in the same way that blood is able to enter).
    However, the information you have provided about pressure variations between the bloodstream and GI has really answered my question. Thank you very much again for your help. Unfortunately this exercise involves ideas that I've not yet studied, which makes it too advanced for me.
    I hope I make sense! I apologise for replying so late, I haven't had any Internet access for a few days.
    Last edited by GRD; 01-03-2010 at 10:49 PM.

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