case study analgesic ( salicylate aspirin poisoning)

[ywith]

Hi,

The case study is a 55-year-old man on long-term analgesic presenting with hypertension 170/105, polyuria and nocturia, Anaemic appearance, very high creatinine and urea (CDK3), hyponatremic and hyerkalemic (Na 129 and K 6.4) with very high proteinuria 1g/24 hour a very slightly high random glucose (6.67), but does not have diabetes mellitus.

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if the analgesic is aspirin this would explain the anaemic appeara via possible GI bleeds. electrolyte imbalances are also in keeping with salicylate overdose. I presume the hypertension is because of the osmotic affect of the salicylate. I can understand that either the hypertension would result in nephrological damage or the nephrological damage resulting hypertension. this nephrological damage may manifest itself as proteinuria.

what confuses me is the hypertension and polyuria result from redistribution of the intracellular fluid into the extracellular fluid by the osmotic effect of salicylate and therefore intracellular fluid is decreasing with the polyuria?

[ywith]

PS. wouldn't the low glomerular filtration rate results in less urine being produced?