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yes.
It's a feedback system based on oxygenation of the EPO-secreting cells in the renal parenchyma. The smoke or pollution increase % CO in the blood and therefore reduce O2 carriage, so resulting in relative hypoxia. This increases the production of EPO by a rather nifty bit of reverse coupling of some ion channel or other.
When you remove the smoke/pollution from the environment, the CO% goes down (over a period of days) and therefore the O2 supply to the cells rises and the EPO output falls. I can't remember the t1/2 for EPO so I'm afraid I can't help with how long this takes but think it is of the order of days following the removal of the stimulus.
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Libs
SGUL GEP
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