|
I am not sure if you've already got the answers to your questions, but here are my thoughts:
1) I think this situation is most likely to arise as a result of an intrinsic malfunction of the filtration apparatus of the kidneys, leading to a low GFR.
2) The movement of water and solutes from the interstitial space to the plasma are mainly dictated by the Starling forces which are determined by the hydrostatic pressures and oncotic pressures in the peritubular capillary and the interstitial space. Normally, the sum of the Starling forces favours the movement of solute and water from the interstitial fluid to the plasma.
3) Renal glycosuria is a benign autosomal recessive defect of tubular reabsorption of glucose, caused by mutations of the sodium/glucose cotransporter SGLT2. Glucose appears in the urine in the presence of a normal blood glucose concentration, as you have mentioned.
|