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Yes, manchester is very notorious for most sort of crimes.
As for knife defence, if you are forced to stand and fight, or at the very least, fight a knife wielding attacker, unless you are very lucky, or the guy is too drunk to stand, you WILL get stabbed or cut, you may take him down eventually, but not before you get a wound to remember him by. The mentality of most such attackers will not be to chase you, they just wont be bothered to run that far, and will either seek a new target or, more likely, wonder off back to the pub.
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