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Plus if you're a bit worried about your reference, you could be totally shameless (like me =P) and pass the Manchester's guide (for referees?) to your referee. =P (For the record, though, my school has an amazingly impressive track record for Medicine applicants, but then again we're not in the UK)
And agree with the posts above that some medical schools take into account your grades relative to your school. I believe Cambridge does that, but I'm not too certain.
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